Grape polyphenols an alternative for synthetic vitamin E

02 May 2023

Grape polyphenols an alternative for synthetic vitamin E

Grape polyphenols (NuxaFen®) can replace synthetic vitamin E in standard and demanding dietary formulations.


NuxaFen®Dry grape extracts (Vitis Vinifera spp. Vinifera, NuxaFen®, Nuproxa Switzerland) contain high levels of polyphenols, including proanthocyanidins, which confer a high antioxidant capacity.


biozyme robapagina

Polyphenols work as antioxidants by:

  quenching free radicals
  chelating metal ions that induce the production of free radicals,

and increasing the activity of antioxidant enzymes such as SOD, CAT and GPx.

biozyme robapagina
Subscribe Now!
Nuproxa international 07-2023
lallemandanimalnutrition eng


Previous studies have shown that NuxaFen® can partially replace synthetic vitamin E in broiler diets without altering zootechnical performance (Dewez et al., 2022).




Evaluate the capacity of NuxaFen® to partially or totally, replace synthetic vitamin E in broilers fed a diet with high levels of polyunsaturated fatty acids, Fe and metabolizable energy (ME).


The study was conducted with the research service of ZOOTEST. Ploufragan and within a commercial barn (GAEC
de La Ville Gestin. Gestin 22640).

One thousand and twenty (1020) day-old ROSS-308 chicks (100% males) were weighed and randomly distributed among 60 pens (N=17 chicks / pen) and 6 treatments (T) (Table 1).

Treatments 1 and 4 were control diets supplemented with 50 mg/kg of vitamin E.
In T 2 and 5, 50% of vitamin E was replaced by 2.3 mg/kg NuxaFen®.

and in T 3 and 6, 100% of vitamin E was replaced by
4.6 mg/kg NuxaFen®.

The replacement ratio was 1:11 (NuxaFen®: vitamin E) on a weigh basis, based on results from previous studies (Dewez et al., 2022).

T4. T5 and T6 were higher in ME and contained 5% of linseed oil and 0.2% of FeS04 to increase
the oxidative stress in the birds (challenged feeds).


The experimental diets were based on wheat, corn and soybean meal and met the nutritional requirements of broilers.

The trial had a duration of 42 days.



Table 1: Treatment Description.

1ME levels for starter diets (1-14 d), growth (15-28 d) and finisher (29-42 d), respectively.


Broilers fed the challenged feeds (Diet B. Figure 1) achieved a lower body weight (BW) at 42 days, nevertheless the only significant difference (p < .05) was observed between T 1 and 3 (higher BW) compared to T6 (lower BW).

Within the type of feed, no differences (p > .05) were observed between treatments.

The lower body weight observed in birds fed the challenged feed was a consequence
of a reduction in feed intake (data not shown).



Figure 1. Body weight at 42 days:


Diet A: standard diet;  Diet B: high ME, with 5%linseed oil and 0.2% FeSO4


The feed conversion rate (FCR) was improved (p <.05) in the birds fed the challenged diet, likely due to the higher ME in these feeds (Figure 2). Among the type of diet, no differences (p > .05) were observed between treatments.


Other measurements recorded during the study, including antioxidant status of the birds and processing yields did not differ (p >.05) between feed type or treatments (data not shown).

Figure 2.  Feed conversion rate at 42 days:


Diet A: standard diet;  Diet B: high ME, with 5% linseed oil and 0.2% FeSO4.



Overall results show no difference in performance of broilers supplemented with synthetic vitamin E ar grape extract either with partial or full replacement.


NuxaFen® can partially or totally replace synthetic vitamin E with a 1:11 ratio, without compromising zootechnical performance.



Dewez et al. (2022). Comparative effect of partial vitamin E replacement with dry grape seed extract (Vitis Vinifera spp. Vinifera) on broiler performance and antioxidant status under stress conditions. World Poultry Congress, Paris.

Content produced by Nuproxa Switzerland Ltd


You may also be interested in: Natural and effective solutions for animal nutrition and welfare(Nuproxa).”

banner special nutrients
Subscribe Now!
lallemandanimalnutrition eng
Latest posts about
banner basf
lallemandanimalnutrition eng
biozyme robapagina
Nuproxa international 07-2023


Subscribe now to the technical magazine of animal nutrition


Access to articles in PDF
Stay up to date with our newsletters
Receive the magazine for free in digital version

AgriFM - Los podcast del sector ganadero en español
agriCalendar - El calendario de eventos del mundo agroganaderoagriCalendar
agrinewsCampus - Cursos de formación para el sector de la ganadería