15 Mar 2022
Tryptophan: impact on the gut microbiota of animals. Gut microbiota and microbial metabolites are important for maintaining healthy intestines. It influences the extent and quality of the immune system’s response; and in turn the immune system is involved in regulating the location and composition of gut microbiota.
Recent studies highlight the profound effects of diet and nutrients on the location and composition of the gut microbiota. In addition to underscoring its connection with immune pathways (Thorburn et al., 2014). 
L-tryptophan (Trp) and its endogenous metabolites are involved in intestinal immune homeostasis. Manipulation of intestinal microbial composition can modulate plasma concentrations of Trp and its metabolites (Clarke et al. , 2014). The microbiome, which consists of microorganisms and their collective genomes, modulates the host’s metabolic phenotype and influences its immune system (Gordon, 2012). Interactions between the gut microbiota and the host’s immune system begin at birth:
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