ALTERION® NE:
CELEBRATING TEN YEARS
OF SCIENCE, INNOVATION AND
GUT HEALTH LEADERSHIP
Damien Prévéraud, Agr Eng, PhD
Global Product Manager Probiotics/Antioxidants
FROM PIONEERING PROBIOTIC SCIENCE TO A GLOBALLY TRUSTED POULTRY SOLUTION
In animal agriculture, true innovation is often measured not by a product launch, but by its ability to stand the test of time. Ten years after its commercial introduction, Alterion® NE has become a widely recognized probiotic solution in poultry production, helping producers around the world improve gut health, resilience and performance through science-based nutrition.
This 10th anniversary marks not only a decade of commercial success, but also a transformative chapter in Adisseo’s evolution from a nutrition company into a broader animal health and nutrition solutions provider.
A VISION BORN IN 2015
The Alterion® NE story began in May 2015 when Adisseo announced the development of innovative probiotic technologies for livestock production.
The objective was to create a probiotic capable of promoting growth performance while limiting the development of undesirable bacteria in the digestive tract.
Continua después de la publicidad.
Innovation is part of Adisseo’s DNA, so expanding our specialty portfolio with probiotics was a natural decision.
THE SEARCH FOR THE RIGHT STRAIN
The success of Alterion® NE can be traced to a rigorous microbial screening program designed to identify a strain capable of delivering measurable and repeatable benefits under commercial production conditions.
Researchers evaluated more than 900 bacterial candidates through extensive in vitro and in vivo screening processes.
The goal was ambitious: discover a strain that combined safety, stability, survivability and biological efficacy. From this effort emerged Bacillus subtilis DSM 29784, a unique spore-forming strain that demonstrated exceptional potential.
The strain’s resilience quickly distinguished it from other probiotic candidates. Its spores could withstand feed manufacturing conditions, maintain viability during storage and successfully reach the poultry intestine where they could become metabolically active.
These characteristics provided the foundation for a probiotic capable of delivering consistent results under real-world conditions.
In 2016, Alterion® NE officially entered the market, opening a new chapter for Adisseo and introducing producers to a scientifically validated approach to gut health management.
UNDERSTANDING WHAT MAKES ALTERION® NE SO UNIQUE
Over the past decade, one of the strongest differentiators of Alterion® NE has been its well-documented mode of action.
Unlike solutions that focus on a single mechanism, Alterion® NE acts simultaneously on three pillars of intestinal resilience:
1
Microbial ecology
2
Gut morphology and intestinal integrity
3
Inflammatory response
After ingestion, Bacillus subtilis DSM 29784 spores germinate in the digestive tract and become metabolically active. The probiotic supports the development of beneficial microbial populations, stimulates bacterial communities associated with nutrient utilization, and helps create a more balanced intestinal ecosystem.
Research has also demonstrated its positive influence on intestinal barrier function. Alterion® NE supports the expression of tight-junction proteins, helping maintain gut integrity and reducing vulnerability to environmental and nutritional challenges. At the same time, it contributes to a more controlled inflammatory response, allowing birds to better cope with stress without compromising performance.
DEEPER INSIGHTS INTO ITS MODE OF ACTION
Recent scientific investigations have provided even deeper insights.
Researchers identified several bioactive metabolites produced by Bacillus subtilis DSM 29784, including hypoxanthine, niacin, and pantothenate. These compounds contribute to epithelial health, immune modulation, and favorable microbiota activity, further explaining the product’s consistent field performance.
DELIVERING RESULTS WHERE IT MATTERS
For poultry producers, performance remains the ultimate measure of value.
Over the past ten years, Alterion® NE has been evaluated through extensive research programs and commercial trials across multiple regions and production systems. The probiotic has consistently demonstrated benefits in growth performance, feed efficiency, and gut health, helping birds maintain productivity under both standard and challenging conditions.
Importantly, its benefits extend beyond simple performance metrics. By enhancing gut resilience, Alterion® NE helps birds better withstand stressors commonly encountered in modern poultry production.
This contributes to improved flock uniformity, greater production predictability, and stronger economic returns for producers.
RECOGNITION THROUGH SCIENCE
The scientific evidence supporting these outcomes has grown steadily year after year.
Today, Alterion® NE’s efficacy and differentiating mode of action are supported by more than twenty publications in peer-reviewed journals, making it one of the most extensively documented probiotic solutions in the poultry sector.
In 2026, the science behind Alterion® NE has been presented at major international scientific conferences: ICPIH (Turkey), IPC (Poland), IPVS (Vietnam), WPC (Canada).
While many products seek industry recognition through marketing claims, Alterion® NE has earned recognition through scientific validation.
A key milestone came with the positive assessment of Bacillus subtilis DSM 29784 by the European Food Safety Authority (EFSA) in 2018, which confirmed both its safety and efficacy for poultry applications.
This regulatory endorsement strengthened confidence throughout the industry and further established Alterion® NE as a trusted solution for producers worldwide.
Beyond regulatory recognition, the product’s greatest achievement may be the reputation it has earned among customers, nutritionists, veterinarians and poultry companies who continue to rely on it after a decade of commercial use.
MORE THAN A PRODUCT: A CATALYST FOR TRANSFORMATION
The Alterion® NE journey has paralleled a broader transformation within Adisseo.
The launch in 2016 accelerated the evolution of Adisseo from a nutrition company into a provider of integrated animal health and nutrition solutions.
Over the years, Alterion® NE has become a flagship example of Adisseo health strategy, integrating microbiology, nutrition, technical expertise and customer support into a comprehensive offering for the poultry industry.
The same year, Alterion® NE received during SPACE (a major international exhibition dedicated to livestock and agricultural production) an Innov’Space award.
LOOKING AHEAD TO THE NEXT DECADE
As Alterion® NE enters its second decade, the ambitions remain high.
Future developments include expansion into additional species, exploration of new markets, optimization of probiotic formulations and continued research into microbial mechanisms and gut resilience. Adisseo also sees Alterion® NE contributing to the long-term development of its animal health portfolio, supporting sustainable livestock production worldwide.
Ten years after its launch, Alterion® NE stands as a powerful example of what can be achieved when microbiology, innovation and customer focus come together.
What began as a pioneering innovation has evolved into a globally trusted solution, supported by science, validated in the field and recognized as a key contributor to poultry gut health and performance.
For Adisseo, the first ten years represent an impressive achievement. For Alterion® NE, they may only be the beginning.
